The main objective of the Cell Biology Unit is to investigate the regulation of gene expression within the sophisticated environment that is the nucleus of a living cell. Presently, the development of gene technologies with therapeutic application is still limited by the lack of basic knowledge concerning the ways in which genes function. The information encoded in genes must be translated into proteins which represent the building blocks of the different tissues in the human body. How gene information turns into protein information can be modulated by a cellular process termed splicing. We are particularly interested in understanding how splicing is regulated and how errors in this process lead to human disease.