Our research interests are focused on the understanding of the molecular mechanisms which lead to neurodegeneration in diseases such as Parkinson's, Huntington's, or Alzheimer's disease. These diseases are intimately associated with protein misfolding and aggregation in specific regions of the brain.
Because the molecular pathways involved in protein homeostasis are highly conserved, we employ a wide variety of model organisms, from the simple but powerful budding yeast to mammalian cell culture and mice, to study the origin of the problems.
Our ultimate goals are to develop novel therapeutic approaches for these and other related disorders. We are working closely together with clinicians in order to accelerate drug discovery efforts, translating basic research into clinical applications that will improve the lives of patients. 

Tiago Fleming Outeiro
PhD (2004) at the Whitehead Institute for Biomedical Research, MIT, EUA
Post-doctoral research at Harvard Medical School and at FoldRx Pharmaceuticals, USA
Co-founder of BioEPI Clinical and Translational Research Center, Portugal 

2007/2009 - SirT2 as a Drug Target in Parkinson's Disease. Michael J. Fox Foundation.

2007/2009 - Unraveling the genetic basis for alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation. Michael J. Fox Foundation.

2007/2009 - Deciphering the Molecular Role of DJ-1 in Parkinson's disease, Fundação Calouste Gulbenkian. Fundação Calouste Gulbenkian.

2007/2011 - NEUROFOLD, Uncovering the Molecular Basis of Neurodegenerative Disorders. Marie Curie Program, European Commission. FP7-Comissão Europeia.

2007/2009 - The molecular effects of the novel ACE mutation Q1069R. American Portuguese Biomedical Research Fund.

2008/2009 - Molecular characterization of the Portuguese population affected by neurodegeneratives disorders. Alto Comissariado para a Saúde.

2009/2011 - Doença de Parkinson de Progressão Lenta e Rápida: Determinantes Moleculares e Biomarcadores. Fundação para a Ciência e a Tecnologia, (PIC/IC/82760/2007).

2009/2011 - Axa Research Fund: Doctoral sponsorship agreement. AXA.

2009/2011 - EMBO Installation Grant. European Molecular Biology Organization.

Flaviano Giorgini (University of Leicester, UK)

 

Aleksey Kazantsev (Massachusetts General Hospital, Harvard Medical School, USA)

 

Fran Borovecki (University of Zagreb, Croatia)

 

Bertrand Joseph (Karolinska Institute, Sweden)

 

Jia-Yi Li (Lund University, Sweden)

 

Hilal Lashuel, EPFL (Switzerland)

 

Jean-Christophe Rochet (Purdue University, USA)

 

Bradley T. Hyman (Massachusetts General Hospital, Harvard Medical School, USA)

 

Poul Jensen (University of Arhus, Denmark)

 

Aaron Gitler (University of Pennsylvania, USA)

Sub-director of Ciência Hoje (www.cienciahoje.pt).

 

Organizer of the Lisbon Area Neuroscience Meetings.

 

Blog of the Scientist an initiative by Ciência Viva, GAPP.

 

Outeiro, T.F., Soares, R., Massada, J., Vinho Tinto e Envelhecimento: Como nos Protegermos de Alzheimer, FNAC Chiado, Lisboa, Portugal. December 2007.

 

Outeiro, T.F., Soares, R., Massada, J., Vinho Tinto e Envelhecimento: Como nos Protegermos de Alzheimer, FNAC Norte Shopping, Porto, Portugal. May 2007.

2008 Aging Research Prize, Portuguese Society for Neuroscience and Pfizer

 

2007 Best Scientific Article, Portuguese Society for Neuroscience

 

2006 Research Talent Award from the Portuguese Government

 

2006 Science Talent Award from the Portuguese Government

 

2003 Young Investigator Award, Gordon Research Conference on Triplet Repeat Disorders

Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner. PLoS One. 2010 Oct 27;5(10):e13700.

 

Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF,  Muchowski PJ, Giorgini F. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. J Biol Chem. 2010 Nov 2. [Epub ahead of print]

 

de Oliveira RM, Pais TF, Outeiro TF. Sirtuins: common targets in aging and in neurodegeneration. Curr Drug Targets. 2010 Oct;11(10):1270-80.

 

Tenreiro S, Outeiro TF. Simple is good: yeast models of neurodegeneration. FEMS Yeast Res. 2010 Dec;10(8):970-9

 

Gonçalves SA, Matos JE, Outeiro TF. Zooming into protein oligomerization in neurodegeneration using BiFC. Trends Biochem Sci. 2010 Nov;35(11):643-51.

 

Vicente Miranda H, Outeiro TF. The sour side of neurodegenerative disorders: the effects of protein glycation. J Pathol. 2010 May;221(1):13-25.

 

Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, Caldwell GA, McCaffery JM, Rochet JC, Lindquist S. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in  Parkinson's disease models. Dis Model Mech. 2010 Mar-Apr;3(3-4):194-208.

 

Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Dopamine-induced conformational changes in alpha-synuclein. PLoS One. 2009 Sep 4;4(9):e6906.

Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, Schlossmacher MG. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Exp Neurol. 2008 Oct;213(2):315-25.
 

Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. PLoS One. 2008 Apr 2;3(4):e1867. Erratum in: PLoS One. 2008;3(5).

 

Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9. Epub 2007 Jun 21.

 

Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Small heat shock proteins protect against alpha-synuclein-induced toxicity and  aggregation. Biochem Biophys Res Commun. 2006 Dec 22;351(3):631-8.

 

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. Epub 2006 Mar 6.

 

Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science. 2003 Dec 5;302(5651):1772-5.

Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science. 2003 Dec 5;302(5651):1769-72.

 

 

Fórum Internacional de Investigadores Portugueses